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Literature summary for 1.14.11.4 extracted from

  • Gong, S.; Wu, C.; Koehler, F.; Meixensberger, J.; Schopow, N.; Kallendrusch, S.
    Procollagen-lysine, 2-oxoglutarate 5-dioxygenase family novel prognostic biomarkers and tumor microenvironment regulators for lower-grade glioma (2022), Front. Cell. Neurosci., 16, 838548 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.4

Application

Application Comment Organism
diagnostics the expression level of the procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) might become a novel biomarker for prognosis and is a potential target for individual treatment decisions in lower-grade glioma (LGG) Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[procollagen]-L-lysine + 2-oxoglutarate + O2 Homo sapiens
-
 [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00469
-
-
Homo sapiens O60568
-
-
Homo sapiens Q02809
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocytoma cell
-
 Homo sapiens
-
oligoastrocytoma
-
 Homo sapiens
-
oligodendroglioma cell the expression of all PLOD family members is higher in astrocytoma than in oligoastrocytoma and oligodendroglioma Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[procollagen]-L-lysine + 2-oxoglutarate + O2
-
 Homo sapiens [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
PLOD
-
 Homo sapiens
PLOD2
-
 Homo sapiens
PLOD3
-
 Homo sapiens
procollagen-lysine,2-oxoglutarate 5-dioxygenase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens highly expressed in lower-grade glioma tumor tissues compared to normal tissues up

General Information

General Information Comment Organism
drug target the expression level of the procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) might become a novel biomarker for prognosis and is a potential target for individual treatment decisions in lower-grade glioma (LGG) Homo sapiens
physiological function procollagen-lysine,2-oxoglutarate 5-dioxygenase (PLOD) family is involved in processes, such as tumor formation and cancer metastasis. A high expression of the PLOD family relates to poor prognosis and high infiltration of immune cells within the tumor microenvironment (TME) Homo sapiens