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Literature summary for 1.14.11.4 extracted from
- Essential roles of insulin, AMPK signaling and lysyl and prolyl hydroxylases in the biosynthesis and multimerization of adiponectin (2015), Mol. Cell. Endocrinol., 399, 164-177 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene Plod1, quantitative RT-PCR enzyme expression analysis | Mus musculus |
| gene Plod3, quantitative RT-PCR enzyme expression analysis | Mus musculus |
| genes Plod2a and Plod2b, quantitative RT-PCR enzyme expression analysis | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | Plod3 knockout by specific siRNA in differentiated 3T3-L1 adipocytes | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dipyridyl | a non-specific hydroxylase inhibitor; a non-specific hydroxylase inhibitor; a non-specific hydroxylase inhibitor | Mus musculus |  |
| minoxidil | specific inhibition of lysyl hydroxylases; specific inhibition of lysyl hydroxylases; specific inhibition of lysyl hydroxylases | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [procollagen]-L-lysine + 2-oxoglutarate + O2 | Mus musculus | - |
[procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9R0B9 | ob/ob mice and age-matched C57/BL littermates as non-obese controls, phenotype comparison, overview | - |
| Mus musculus | Q9R0E1 | ob/ob mice and age-matched C57/BL littermates as non-obese controls, phenotype comparison, overview | - |
| Mus musculus | Q9R0E2 | ob/ob mice and age-matched C57/BL littermates as non-obese controls, phenotype comparison, overview | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 3T3-L1 cell | - |
Mus musculus | - |
| adipocyte | - |
Mus musculus | - |
| white adipose tissue | lysyl hydroxylases are expressed in white-adipose tissue of ob/ob mice, overview | Mus musculus | - |
| white adipose tissue | lysyl hydroxylases are expressed in white-adipose tissue of ob/ob mice, wherein LH3 levels are increased compared with C57/BL controls. Expression levels of mRNAs corresponding to LH1 (Plod1) and LH3 (Plod3) are both altered in ob/ob mice, in the same direction as the changes in serum levels of adiponectin and the HMW isoforms | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [procollagen]-L-lysine + 2-oxoglutarate + O2 | - |
Mus musculus | [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LH1 | - |
Mus musculus |
| LH2a | - |
Mus musculus |
| LH2b | - |
Mus musculus |
| LH3 | - |
Mus musculus |
| Plod1 | - |
Mus musculus |
| Plod2a | - |
Mus musculus |
| Plod2b | - |
Mus musculus |
| PLOD2iso1 | - |
Mus musculus |
| PLOD2iso2 | - |
Mus musculus |
| PLOD3 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | inhibition of prolyl hydroxylation and lysyl hydroxylation/glycosylation affects on adiponectin production, pharmacological LH inhibition causes significant suppression of adiponectin production, more particularly of the higher-order isoforms | Mus musculus |
| malfunction | inhibition of prolyl hydroxylation and lysyl hydroxylation/glycosylation affects on adiponectin production, pharmacological LH inhibition causes significant suppression of adiponectin production, more particularly of the higher-order isoforms. Transient gene knock-down of LH3 encoding gene Plod3 causes a suppressive effect, especially on the high molecular-weight (HMW) isoforms | Mus musculus |
| metabolism | essential roles of insulin, AMPK signaling and lysyl and prolyl hydroxylases in the biosynthesis and multimerization of adiponectin, pathway regulation, detailed overview | Mus musculus |
| physiological function | the family of lysyl hydroxylases is responsible for catalyzing the hydroxylation of protein-bound lysyl residues to yield hydroxylysyl residues, which can then undergo subsequent glycosylation. Lysyl and prolyl hydroxylases are both required for physiological adiponectin production and in particular are essential for the formation/secretion of the HMW isoforms | Mus musculus |
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