Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.4 extracted from

  • Dayer, C.; Stamenkovic, I.
    Recruitment of matrix metalloproteinase-9 (MMP-9) to the fibroblast cell surface by lysyl hydroxylase 3 (LH3) triggers transforming growth factor-beta (TGF-beta) activation and fibroblast differentiation (2015), J. Biol. Chem., 290, 13763-13778 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene PLOD3 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-
endoplasmic reticulum
-
Homo sapiens 5783
-
extracellular the enzyme is secreted Homo sapiens
-
-
additional information lysyl hydroxylase 3 is a multifunctional protein that localizes to the endoplasmic reticulum but is also secreted into the extracellular space and is associated with collagenous proteins on the cell surface Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[procollagen]-L-lysine + 2-oxoglutarate + O2 Homo sapiens
-
[procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60568
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[procollagen]-L-lysine + 2-oxoglutarate + O2
-
Homo sapiens [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
LH3
-
Homo sapiens
lysyl hydroxylase 3
-
Homo sapiens
PLOD3
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme LH3 downregulation decreases MMP-9 recruitment to MRC-5 and thus MMP-9/LH3 interaction Homo sapiens
physiological function recruitment of matrix metalloproteinase-9 (MMP-9) to the fibroblast cell surface by lysyl hydroxylase 3 triggers transforming growth factor-beta (TGF-beta) activation and fibroblast differentiation. LH3 provides the docking mechanism for MMP-9 cell surface association via the MMP-9 FN domain. Recruitment of MMP-9 to fibroblast cell surface does not depend merely on LH3 expression at the cell membrane. LH3 provides a mechanism for deployment of MMP-9 catalytic activity at the fibroblast cell surface that promotes TGF-beta activation and the corresponding enhancement of alpha-SMA expression. MMP-9-induced TGF-beta activation promotes alpha-SMA expression in fibroblasts is consistent with a function that supports tumor progression. LH3 expressed in a variety of tumor cell types fails to recruit MMP-9 to their cell surface Homo sapiens