Protein Variants | Comment | Organism |
---|---|---|
D669A | site-directed mutagenesis, inactive mutant | Mus musculus |
additional information | generation of an LH3 knockout line, the LH32/2 knockout embryonic fibroblasts totally lack the LH3 protein | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus C57BL/6 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
LH3 | - |
Mus musculus |
lysyl hydroxylase 3 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | lack of LH3 prevents the formation of hydroxylysine linked Glc-Gal structures in collagen. Secretion of type IV collagen is blocked in embryos that lack LH3 catalyzed Glc-Gal-Hyl residues, and this disrupts formation of the basement membranes that support tissues e.g. blood vessels. Changes in the lysyl hydroxylase activity of LH3 affect the adiponectin level and modifications in mouse, its secretion and oligomer distribtion, phenotype, overview. Recombinant adiponectin produced in LH3-/- knockout fibroblasts cells does not form middle molecular weight and high molecular weight oligomers | Mus musculus |
physiological function | regulation of the posttranslational lysine modifications in the collagenous domain is the key event in determining the function of adiponectin, changes in the lysyl hydroxylase activity of LH3 affect the adiponectin level and modifications in mouse, its secretion and oligomer distribtion | Mus musculus |