Protein Variants | Comment | Organism |
---|---|---|
E542A | site-directed mutagenesis | Homo sapiens |
E542A/E547A | site-directed mutagenesis | Homo sapiens |
E542A/E547A/E574A/E579A | site-directed mutagenesis | Homo sapiens |
E542A/E547A/E574A/E579A/E560A | site-directed mutagenesis | Homo sapiens |
E542A/H546L/E547A | site-directed mutagenesis | Homo sapiens |
E542A/Q543L/Y544F/E547A/E574A | site-directed mutagenesis | Homo sapiens |
E547A | site-directed mutagenesis | Homo sapiens |
E579A/E560A | site-directed mutagenesis | Homo sapiens |
K541M | site-directed mutagenesis | Homo sapiens |
K541M/E542A | site-directed mutagenesis | Homo sapiens |
additional information | monomerization inactivates the LH activity of LH3, distribution of monomers, dimers, and multimers in mutant enzyme structures, overview. Glycosyltransferase activity of the mutant enzymes, overview | Homo sapiens |
Q543L/Y544F | site-directed mutagenesis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[procollagen] + 2-oxoglutarate + O2 | Homo sapiens | - |
(2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? | |
additional information | Homo sapiens | lysyl hydroxylase 3 is a multifunctional enzyme of collagen biosynthesis, with glycosyltransferase activity and lysyl hydroxylase activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[procollagen] + 2-oxoglutarate + O2 | - |
Homo sapiens | (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? | |
L-lysine-[procollagen] + 2-oxoglutarate + O2 | the hydroxylysyl residues are located in Y positions of X-Y-Gly repeats of collagenous sequences | Homo sapiens | (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? | |
additional information | lysyl hydroxylase 3 is a multifunctional enzyme of collagen biosynthesis, with glycosyltransferase activity and lysyl hydroxylase activity | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | localization of the region responsible for the dimerization of lysyl hydroxylase 3, to a sequence of amino acids between the glycosyltransferase activity and the lysyl hydroxylase activity domains. This area is covered by amino acids 541-547 and contains no cysteine residues | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
LH3 | - |
Homo sapiens |
lysyl hydroxylase 3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | heterocomplex formation between mouse and human LH3, between human LH1 and LH3 and between human LH2 and LH3, low amount of complexes formed in vivo | Homo sapiens |