Literature summary for 1.14.11.4 extracted from

Yeowell, H.N.; Walker, L.C.; Mauger, D.M.; Seth, P.; Garcia-Blanco, M.A.
TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2 (2009), J. Invest. Dermatol., 129, 1402-1411.

Search for more literature for 1.14.11.4

Cloned(Commentary)

Cloned (Comment)	Organism
endogenous LH2 alternate splicing pattern and conservation analysis of LH2 genomic sequence., overview. Construction and expression of a functional LH2 minigene in HEK-293 cells, human neonatal skin fibroblasts, and mouse embryonic fibroblasts. The TIA proteins play a role in the regulation of the alternative splicing of LH2, overview	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	siRNA knockdowns of TIA-1 and TIAL1 both singly and in combination in HEK293 cells decrease the ratio of LH2 (long) to LH2 (short) splicing variants	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozyme LH2	-

Synonyms

Synonyms	Comment	Organism
lysyl hydroxylase 2	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	reduction of TIA protein levels in mous embryonic fibroblasts and HEK-293 cells leads to a corresponding decrease in the LH2(long) spliced product in both the minigene and the endogenous gene	down
Homo sapiens	overexpression of the TIA proteins in HEK-293 cells leads to an increase in levels of the LH2(long) spliced product in the minigene	up

General Information

General Information	Comment	Organism
malfunction	although differential expression of LH2 (long) is associated with fibrotic conditions, there is no direct evidence that the increased Pyr cross-links in the overaccumulated collagen contribute definitively to fibrosis	Homo sapiens

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Release 2023.1 (January 2023)