Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | non-heme Fe2+ is required for activity | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA-1-methyladenine + 2-oxoglutarate + O2 | this reaction occurs on both single- and double-stranded DNA | Escherichia coli | DNA-adenine + formaldehyde + succinate + CO2 | - |
? | |
DNA-3-methylcytosine + 2-oxoglutarate + O2 | this reaction occurs on both single- and double-stranded DNA | Escherichia coli | DNA-cytosine + formaldehyde + succinate + CO2 | - |
? | |
additional information | AlkB preferentially binds and reactivates methylated single-stranded DNA | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AlkB | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | the alkB gene product protects against cell killing by SN2-alkylating agents, probably through DNA repair | Escherichia coli |