Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required for activity | Escherichia coli | |
Fe2+ | required for activity | Homo sapiens | |
Mg2+ | the double-stranded DNA preference of isoform ABH2 is observed only in the presence of magnesium, the presence of magnesium stimulates the activity of isoform ABH2 on double-stranded DNA, but inhibits its activity on single-stranded DNA (maximal effect is observed in the presence of 10 mM MgCl2) | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA-1-methyladenine + 2-oxoglutarate + O2 | - |
Escherichia coli | DNA-adenine + formaldehyde + succinate + CO2 | - |
? | |
DNA-1-methyladenine + 2-oxoglutarate + O2 | - |
Homo sapiens | DNA-adenine + formaldehyde + succinate + CO2 | - |
? | |
DNA-3-methylcytosine + 2-oxoglutarate + O2 | - |
Escherichia coli | DNA-cytosine + formaldehyde + succinate + CO2 | - |
? | |
DNA-3-methylcytosine + 2-oxoglutarate + O2 | - |
Homo sapiens | DNA-cytosine + formaldehyde + succinate + CO2 | - |
? | |
methylated poly(deoxyadenine) + 2-oxoglutarate + O2 | the activity of AlkB on methylated poly(deoxyadenine) annealed to unmethylated poly(deoxythymine) is 3fold higher than with methylated poly(deoxyadenine) alone | Escherichia coli | poly(deoxyadenine) + formaldehyde + succinate + CO2 | - |
? | |
additional information | AlkB prefers single-stranded DNA and RNA | Escherichia coli | ? | - |
? | |
additional information | isoform ABH3 prefers single-stranded DNA (also under magnesium-free conditions) and RNA, while isoform ABH2 prefers double-stranded DNA (only in the presence of magnesium) and RNA | Homo sapiens | ? | - |
? | |
RNA-1-methyladenine + 2-oxoglutarate + O2 | - |
Escherichia coli | RNA-adenine + formaldehyde + succinate + CO2 | - |
? | |
RNA-1-methyladenine + 2-oxoglutarate + O2 | - |
Homo sapiens | RNA-adenine + formaldehyde + succinate + CO2 | - |
? | |
RNA-3-methylcytosine + 2-oxoglutarate + O2 | - |
Escherichia coli | RNA-cytosine + formaldehyde + succinate + CO2 | - |
? | |
RNA-3-methylcytosine + 2-oxoglutarate + O2 | - |
Homo sapiens | RNA-cytosine + formaldehyde + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ABH2 | isoform | Homo sapiens |
ABH3 | isoform | Homo sapiens |
AlkB | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | - |
Escherichia coli | |
2-oxoglutarate | - |
Homo sapiens |