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Literature summary for 1.14.11.30 extracted from

  • Ma, M.; Hua, S.; Li, G.; Wang, S.; Cheng, X.; He, S.; Wu, P.; Chen, X.
    Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma (2017), Oncotarget, 8, 12983-13002 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 Homo sapiens
-
hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocellular carcinoma cell
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2
-
Homo sapiens hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
factor inhibiting HIF-1
-
Homo sapiens
FIH
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is reduced in hepatocellular carcinoma down

General Information

General Information Comment Organism
malfunction the lower enzyme expression in tumor is associated with incomplete tumor encapsulation, vascular invasion, and microvascular density Homo sapiens