Literature summary for 1.14.11.30 extracted from

Chan, M.C.; Ilott, N.E.; Schoedel, J.; Sims, D.; Tumber, A.; Lippl, K.; Mole, D.R.; Pugh, C.W.; Ratcliffe, P.J.; Ponting, C.P.; Schofield, C.J.
Tuning the transcriptional response to hypoxia by inhibiting hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases (2016), J. Biol. Chem., 291, 20661-20673 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-oxalyl-D-phenylalanine	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2	Homo sapiens	-	hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2	-	Homo sapiens	hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
factor inhibiting HIF	-	Homo sapiens
FIH	-	Homo sapiens

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Release 2023.1 (January 2023)