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Literature summary for 1.14.11.29 extracted from

  • Dengler, F.; Sova, S.; Salo, A.M.; Maeki, J.M.; Koivunen, P.; Myllyharju, J.
    Expression and roles of individual HIF prolyl 4-hydroxylase isoenzymes in the regulation of the hypoxia response pathway along the murine gastrointestinal epithelium (2021), Int. J. Mol. Sci., 22, 4038 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 Mus musculus
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 hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BG58
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic epithelium
-
 Mus musculus
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jejunum
-
 Mus musculus
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pyloric cecum
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
-
 Mus musculus hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
HIF prolyl 4-hydroxylase
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 Mus musculus
HIF-P4H-1
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 Mus musculus
HIF-P4H-2
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 Mus musculus
HIF-P4H-3
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus at 8 weeks of age the Hif-p4h isoforms 1, 2 and 3 are expressed in the jejunum epithelium at similar levels of 27, 35 and 29 copies/fg RNA. At 3 and 16 weeks of age, Hif-p4h-3 seems to have a slightly higher expression level than the other two isoforms. The caecum epithelium, Hif-p4h-2 has the highest abundance (109 copies/fg RNA input at 8 weeks of age) of the Hif-p4h isoforms, which is significantly higher when compared to Hif-p4h-3 (39 copies/fg RNA input). In the colon epithelium Hif-p4h-2 mRNA has the highest abundance (44 copies/fg RNA input) among the Hif-p4h isoforms, which is significantly higher than that of Hif-p4h-1 (18 copies/fg RNA input) and Fih1 (15 copies/fg RNA input), while the difference between the Hif-p4h-2 and Hif-p4h-3 (30 copies/fg RNA input) mRNA levels do not reach statistical significance up

General Information

General Information Comment Organism
physiological function the HIF prolyl 4-hydroxylases (HIF-P4H) controls hypoxia-inducible factor (HIF), a powerful mechanism regulating cellular adaptation to decreased oxygenation. HIF-P4H-2 plays a major role in the regulation of hypoxic signalling in murine jejunum epithelium Mus musculus