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Literature summary for 1.14.11.29 extracted from

  • Cockman, M.E.; Lippl, K.; Tian, Y.M.; Pegg, H.B.; Figg, W.D.; Abboud, M.I.; Heilig, R.; Fischer, R.; Myllyharju, J.; Schofield, C.J.; Ratcliffe, P.J.
    Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates (2019), eLife, 8, e46490 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.29

Cloned(Commentary)

Cloned (Comment) Organism
expression in H5 insect cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96KS0
-
-
Homo sapiens Q9GZT9
-
-
Homo sapiens Q9H6Z9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxia-inducible factor HIF1alpha-L-proline + 2-oxoglutarate + O2
-
 Homo sapiens hypoxia-inducible factor HIF1alpha-trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
hypoxia-inducible factor HIF2alpha-L-proline + 2-oxoglutarate + O2
-
 Homo sapiens hypoxia-inducible factor HIF2alpha-trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
hypoxia-inducible factor HIF3alpha-L-proline + 2-oxoglutarate + O2
-
 Homo sapiens hypoxia-inducible factor HIF3alpha-trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
additional information prolyl hydroxylation is not assigned on any of the teste non-HIF substrate sites. Recombinant PHD enzymes provide no support for the wide range of non-HIF PHD substrates reported Homo sapiens ?
-
-

Synonyms

Synonyms Comment Organism
EGLN1
-
 Homo sapiens
Egln2
-
 Homo sapiens
EGLN3
-
 Homo sapiens
PHD1
-
 Homo sapiens
PHD2
-
 Homo sapiens
PHD3
-
 Homo sapiens