Literature summary for 1.14.11.27 extracted from

Liu, H.; Wang, C.; Lee, S.; Deng, Y.; Wither, M.; Oh, S.; Ning, F.; Dege, C.; Zhang, Q.; Liu, X.; Johnson, A.M.; Zang, J.; Chen, Z.; Janknecht, R.; Hansen, K.; Marrack, P.; Li, C.Y.; Kappler, J.W.; Hagman, J.; Zhang, G.
Clipping of arginine-methylated histone tails by JMJD5 and JMJD7 (2017), Proc. Natl. Acad. Sci. USA, 114, E7717-E7726 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P0C870	cf. EC 1.14.11.63	-
Homo sapiens	Q8N371	cf. EC 1.14.11.73	-

Synonyms

Synonyms	Comment	Organism
JMJD5	-	Homo sapiens
JMJD7	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	JMJD5 has divalent cation-dependent protease activities that preferentially cleave the tails of histones 2, 3, or 4 containing methylated arginines. After the initial specific cleavage, JMJD5 acting as aminopeptidase, progressively digests the C-terminal products. JMJD5-deficient fibroblasts exhibit dramatically increased levels of methylated arginines and histones	Homo sapiens
physiological function	JMJD5 has divalent cation-dependent protease activities that preferentially cleave the tails of histones 2, 3, or 4 containing methylated arginines. After the initial specific cleavage, JMJD5 acting as aminopeptidase, progressively digests the C-terminal products. JMJD5-deficient fibroblasts exhibit dramatically increased levels of methylated arginines and histones. Depletion of JMJD7 in breast cancer cells greatly decreases cell proliferation	Homo sapiens

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Release 2023.1 (January 2023)