Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of a jhd1DELTA deletion mutant, phenotype overview | Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required for catalysis | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 | Saccharomyces cerevisiae | - |
histone H3 N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
additional information | Saccharomyces cerevisiae | enzyme Jhd1 is also active on H3K9 methyl groups | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P40034 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 | - |
Saccharomyces cerevisiae | histone H3 N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
additional information | enzyme Jhd1 is also active on H3K9 methyl groups | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Jhd1 | - |
Saccharomyces cerevisiae |
KDM4 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | changes in RENT component recruitment at NTS regions due to loss of H3 methylases or demethylases | Saccharomyces cerevisiae |
metabolism | different roles of histone H3 methylases in regulating Net1/Sir2 recruitment to rDNA regions and the resultant rDNA silencing. In particular, both H3K4 and H3K79 methylation by Set1 and Dot1 positively regulate rDNA silencing, whereas H3K36 methylation by Set2 has the opposite effect | Saccharomyces cerevisiae |
physiological function | changes in histone H3 lysine methylation levels distinctly regulate rDNA silencing by recruiting different silencing proteins to rDNA, thereby contributing to rDNA silencing and nucleolar organization in yeast. Jhd1 positively affects transcription | Saccharomyces cerevisiae |