Crystallization (Comment) | Organism |
---|---|
recombinant isozyme CAS1, hanging drop method, 2 M ammonium sulfate, 0.1 M Tris, 21°C, apoform crystals or in complex with Fe2+, N-alpha-acetyl-L-arginine, and the substrates 2-oxoglutarate and proclavaminate, X-ray diffraction structure determination for native and heavy atom derivatives and analysis | Streptomyces clavuligerus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | - |
Streptomyces clavuligerus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces clavuligerus | Q05581 | recombinant CAS1 | - |
Streptomyces clavuligerus | Q05581 | crystal structure of isozyme CAS1, complexed or uncomplexed, recombinant from Escherichia coli, Protein Data Bank: 1DS0, 1DS1, 1DRY, 1DRT, 1GVG | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O | reaction mechanism | Streptomyces clavuligerus | |
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O | substrate-binding mechanism | Streptomyces clavuligerus | |
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O | reaction mechanism | Streptomyces clavuligerus | |
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O | substrate-binding mechanism | Streptomyces clavuligerus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 | this reaction is due to a proclavaminate amidinohydrolase, i.e. cla | Streptomyces clavuligerus | amidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 | hydroxylation | Streptomyces clavuligerus | guanidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
dihydroclavaminate + 2-oxoglutarate + O2 | cyclization | Streptomyces clavuligerus | clavaminate + succinate + CO2 + H2O | - |
? | |
additional information | substrate-binding | Streptomyces clavuligerus | ? | - |
? | |
additional information | dependent on O2 and 2-oxoglutarate | Streptomyces clavuligerus | ? | - |
? | |
N-alpha-acetyl-L-arginine + 2-oxoglutarate + O2 | hydroxylation | Streptomyces clavuligerus | 4-hydroxy-N-alpha-acetyl-L-arginine + succinate + CO2 + H2O | - |
? | |
N-alpha-acetyl-L-arginine + 2-oxoglutarate + O2 | isozyme CAS1 | Streptomyces clavuligerus | 4-hydroxy-N-alpha-acetyl-L-arginine + succinate + CO2 + H2O | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | saturation | Streptomyces clavuligerus | dihydroclavaminate + succinate + CO2 + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CAS | - |
Streptomyces clavuligerus |