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Literature summary for 1.14.11.20 extracted from
- Enhancement of vindoline and vinblastine production in suspension-cultured cells of Catharanthus roseus by artemisinic acid elicitation (2013), World J. Microbiol. Biotechnol., 30, 175-180.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene D4H, semi-quantitative RT-PCR expression analysis | Catharanthus roseus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deacetoxyvindoline + 2-oxoglutarate + O2 | Catharanthus roseus | - |
deacetylvindoline + succinate + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Catharanthus roseus | - |
gene D4H | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell suspension culture | - |
Catharanthus roseus | - |
| leaf | - |
Catharanthus roseus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deacetoxyvindoline + 2-oxoglutarate + O2 | - |
Catharanthus roseus | deacetylvindoline + succinate + CO2 | - |
? | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Catharanthus roseus | artemisinic acid leads to upregulation of the deacetoxyvindoline 4-hydroxylase and upstream enzymes of the vinblastine biosynthesis, i.e. tryptophan decarboxylase, geraniol 10-hydroxylase, tabersonine 16-hydroxylase | up |
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