Literature summary for 1.14.11.17 extracted from

Ali, H.S.; de Visser, S.P.
Electrostatic perturbations in the substrate-binding pocket of taurine/alpha-ketoglutarate dioxygenase determine its selectivity (2022), Chemistry, 28, e202104167 .

Search for more literature for 1.14.11.17

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
taurine + 2-oxoglutarate + O2	Escherichia coli	-	sulfite + aminoacetaldehyde + succinate + CO2	-	?
taurine + 2-oxoglutarate + O2	Escherichia coli K12	-	sulfite + aminoacetaldehyde + succinate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P37610	-	-
Escherichia coli K12	P37610	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
taurine + 2-oxoglutarate + O2	-	Escherichia coli	sulfite + aminoacetaldehyde + succinate + CO2	-	?
taurine + 2-oxoglutarate + O2	calculations using large cluster models that include key hydrogen bonding interactions in the substrate binding pocket and His70 protonated reproduce experimental rates and selectivity excellently and give a dominant C1-hydroxylation channel leading to R-1-hydroxytaurine products. This is triggered by charged active site residues including a protonated His70 group	Escherichia coli	sulfite + aminoacetaldehyde + succinate + CO2	-	?
taurine + 2-oxoglutarate + O2	-	Escherichia coli K12	sulfite + aminoacetaldehyde + succinate + CO2	-	?
taurine + 2-oxoglutarate + O2	calculations using large cluster models that include key hydrogen bonding interactions in the substrate binding pocket and His70 protonated reproduce experimental rates and selectivity excellently and give a dominant C1-hydroxylation channel leading to R-1-hydroxytaurine products. This is triggered by charged active site residues including a protonated His70 group	Escherichia coli K12	sulfite + aminoacetaldehyde + succinate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
TauD	-	Escherichia coli
taurine/alpha-ketoglutarate dioxygenase	-	Escherichia coli

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Release 2023.1 (January 2023)