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Literature summary for 1.14.11.17 extracted from
- Cr(II) reactivity of taurine/alpha-ketoglutarate dioxygenase (2007), Inorg. Chem., 46, 10087-10092.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Y73F | active, but mutant is incapable of formation of a Cr(III)-semiquinone chromophore | Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cr2+ | Cr(II) replaces Fe2+ and binds stoichiometrically with 2-oxoglutarate to the Fe(II)/2-oxoglutarate binding site of the protein, with additional Cr(II) used to generate a chromophore attributed to a Cr(III)-semiquinone in a small percentage of the sample. Formation of the semiquinone requires the dihydroxyphenylalanine quinone form of Y73, generated by intracellular self-hydroxylation | Escherichia coli |  |
| Fe2+ | - |
Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
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Release 2023.1 (January 2023)
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