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Literature summary for 1.14.11.17 extracted from
- Kinetic and spectroscopic investigation of CoII, NiII, and N-oxalylglycine inhibition of the FeII/alpha-ketoglutarate dioxygenase, TauD (2005), Biochem. Biophys. Res. Commun., 338, 191-197.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | IC50: 0.0019 mM, in the presence of Fe2+; IC50: 0.041 mM | Escherichia coli |  |
| N-oxalylglycine | - |
Escherichia coli | |
| Ni2+ | IC50: 0.00071 mM, in the presence of Fe2+; IC50: 0.032 mM | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| DEAE-Sepharose column chromatography and HP phenyl-Sepharose column chromatography | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| taurine + 2-oxoglutarate + O2 | - |
Escherichia coli | sulfite + aminoacetaldehyde + succinate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TauD | - |
Escherichia coli |
| taurine/alpha-ketoglutarate-dependent dioxygenase | - |
Escherichia coli |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.29 | - |
N-oxalylglycine | - |
Escherichia coli | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00071 | - |
IC50: 0.00071 mM, in the presence of Fe2+ | Escherichia coli | Ni2+ | |
| 0.0019 | - |
IC50: 0.0019 mM, in the presence of Fe2+ | Escherichia coli | Co2+ | |
| 0.032 | - |
IC50: 0.032 mM | Escherichia coli | Ni2+ | |
| 0.041 | - |
IC50: 0.041 mM | Escherichia coli | Co2+ | |
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