Literature summary for 1.14.11.16 extracted from

Huang, C.K.; Iwagami, Y.; Zou, J.; Casulli, S.; Lu, S.; Nagaoka, K.; Ji, C.; Ogawa, K.; Cao, K.Y.; Gao, J.S.; Carlson, R.I.; Wands, J.R.
Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation (2018), Cancer Lett., 429, 1-10 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8BSY0	-	-

Synonyms

Synonyms	Comment	Organism
aspartate beta-hydroxylase	-	Mus musculus
ASPH	-	Mus musculus

General Information

General Information	Comment	Organism
drug target	the enzyme (ASPH) may be a potential therapeutic target in CCA patients having the IDH1/2 wild-type genotype	Mus musculus
malfunction	knockdown of enzyme (ASPH) expression inhibits cholangiocarcinoma development and growth by reducing retinoblastoma protein (RB1) inhibition	Mus musculus
physiological function	the enzyme (ASPH) is involved in cholangiocarcinoma growth, progression and induction of cell senescence. The protein interaction between RB1 and the CDK complexes is modulated by ASPH expression	Mus musculus

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Release 2023.1 (January 2023)