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Literature summary for 1.14.11.16 extracted from

  • Dong, X.; Lin, Q.; Aihara, A.; Li, Y.; Huang, C.K.; Chung, W.; Tang, Q.; Chen, X.; Carlson, R.; Nadolny, C.; Gabriel, G.; Olsen, M.; Wands, J.R.
    Aspartate beta-hydroxylase expression promotes a malignant pancreatic cellular phenotype (2015), Oncotarget, 6, 1231-1248 .
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
86000
-
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q12797
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic ductal adenocarcinoma cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
ASPH
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is highly overexpressed in pancreatic cancer. Upregulation of the enzyme confers a malignant phenotype characterized by enhanced cell proliferation, migration, invasion and colony formation in vitro as well as pancreatic cancer tumor growth in vivo. The transforming properties of aspartate beta-hydroxylase depend on enzymatic activity up

General Information

General Information Comment Organism
drug target a small molecule inhibitor (MO-I-1100) of beta-hydroxylase activity is developed and found to reduce pancreatic cancer growth by downregulating the Notch signaling pathway Homo sapiens
metabolism the enzyme catalyzes the hydroxylation of epidermal growth factor (EGF)-like repeats in Notch receptors and ligands. It is highly overexpressed in pancreatic cancer. The upregulation confers a malignant phenotype characterized by enhanced cell proliferation, migration, invasion and colony formation in vitro as well as pancreatic cancer tumor growth in vivo. The transforming properties of aspartate beta-hydroxylase depend on enzymatic activity. The enzyme links pancreatic cancer growth factor signaling cascades to Notch activation Homo sapiens