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Literature summary for 1.14.11.16 extracted from

  • Borgas, D.L.; Gao, J.S.; Tong, M.; Roper, N.; de la Monte, S.M.
    Regulation of aspartyl-(asparaginyl)-?-hydroxylase protein expression and function by phosphorylation in hepatocellular carcinoma cells (2015), J. Nat. Sci., 1, e84 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine insulin/IGF-1 stimulation of asparaginyl-beta-hydroxylase and Notch are enhanced by inhibiting kinases that could phosphorylate asparaginyl-beta-hydroxylase protein. Targeted manipulation of the phosphorylation state of asparaginyl-beta-hydroxylase may have therapeutic value for reducing asparaginyl-beta-hydroxylase-Notch activation and attendant infiltrative growth of hepatocellular carcinomas Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm the pattern of diffuse cytoplasmic staining iss reticular or particulate, consistent with the known microsomal and mitochondrial distributions of the enzyme Homo sapiens 5737
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q12797
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-

Source Tissue

Source Tissue Comment Organism Textmining
Huh-7 cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
aspartyl-(asparaginyl)-beta-hydroxylase
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens IGF-1 stimulation increases asparaginyl-beta-hydroxylase protein expression and shifts localization of asparaginyl-beta-hydroxylase from the perinuclear zone to the cell periphery, including podocytes. Subsequently, Notch-1 intracellular domain is translocated to the nucleus, which is critical for Notch-modulated gene expression. Besides glycogen synthase kinase-3beta, inhibition of protein kinase C, protein kinase A, and casein kinase 2, which can potentially phosphorylate asparaginyl-beta-hydroxylase, increases IGF-1 stimulated asparaginyl-beta-hydroxylase protein. Insulin and LiCl independently and additively increase long-term asparaginyl-beta-hydroxylase protein expression up