Literature summary for 1.14.11.16 extracted from

Coleman, M.L.; McDonough, M.A.; Hewitson, K.S.; Coles, C.; Mecinovic, J.; Edelmann, M.; Cook, K.M.; Cockman, M.E.; Lancaster, D.E.; Kessler, B.M.; Oldham, N.J.; Ratcliffe, P.J.; Schofield, C.J.
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor (2007), J. Biol. Chem., 282, 24027-24038.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
enzyme in complex with peptides of Notch receptor. Significant conformational changes are required in the ankyrin repeat fold of Notch receptor to enable hydroxylation	Mus musculus
enzyme in complex with peptides of Notch receptor. Significant conformational changes are required in the ankyrin repeat fold of Notch receptor to enable hydroxylation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
ankyrin repeat domain	may function as a natural inhibitor and provide an oxygen-dependent interface that modulates hypoxia-induced factor signaling	Homo sapiens
ankyrin repeat domain	may function as a natural inhibitor and provide an oxygen-dependent interface that modulates hypoxia-induced factor signaling	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ankyrin repeat domain of endogenous Notch receptor L-asparagine + 2-oxoglutarate + O2	hydroxylation of highly conserved asparaginyl residues within the ankyrin repeat	Homo sapiens	ankyrin repeat domain of endogenous Notch receptor 3-hydroxy-L-asparagine + succinate + CO2	-	?
ankyrin repeat domain of endogenous Notch receptor L-asparagine + 2-oxoglutarate + O2	hydroxylation of hyghly conserved asparaginyl residues within the ankyrin repeat	Mus musculus	ankyrin repeat domain of endogenous Notch receptor 3-hydroxy-L-asparagine + succinate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
factor inhibiting HIF	-	Homo sapiens
HIF asparaginyl hydroxylase	-	Homo sapiens

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Release 2023.1 (January 2023)