Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-Trimethylammoniobutanoate | substrate inhibition associated with age is observed at concentrations above 0.6 mM | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in liver of 1-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.025 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in liver of 7-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.026 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in liver of 56-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.032 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in kidney of 1-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.037 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in kidney of 56-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.038 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in liver of 21-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.041 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in liver of 35-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.053 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in liver of newborn domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.06 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in liver of 210-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.061 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in kidney of 7-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.063 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in kidney of 21-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.074 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in kidney of 210-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.086 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in kidney of 35-day-old domestic pig, pH 7.4, 37°C | Sus scrofa | |
0.119 | - |
4-Trimethylammoniobutanoate | apparent kinetic constant (Km), in kidney of newborn domestic pig, pH 7.4, 37°C | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-trimethylammoniobutanoate + 2-oxoglutarate + O2 | Sus scrofa | - |
3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | F1SGL4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | from newborn and 1-, 7-, 21-, 35-, 56-, and 210-day-old domestic pigs. The predominant organ for carnitine synthesis is likely the kidney at birth. The liver appears to predominate after the pig exceeds 7 days of age | Sus scrofa | - |
liver | from newborn and 1-, 7-, 21-, 35-, 56-, and 210-day-old domestic pigs. The predominant organ for carnitine synthesis is likely the kidney at birth. The liver appears to predominate after the pig exceeds 7 days of age | Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-trimethylammoniobutanoate + 2-oxoglutarate + O2 | - |
Sus scrofa | 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gamma-BBH | - |
Sus scrofa |
gamma-butyrobetaine hydroxylase | - |
Sus scrofa |
Organism | Comment | Expression |
---|---|---|
Sus scrofa | hepatic activity is low at birth but increases after 1 day. By 21 days, the activity rises by 6.6fold and remains constant after 56 days. Renal activity is higher than in liver at birth but remains constant through 35 days. By 56 days, the velocity increases by 44% over the activity at birth | up |
General Information | Comment | Organism |
---|---|---|
metabolism | last limiting enzyme of the L-carnitine biosynthesis pathway and plays an important role in catalyzing the hydroxylation of gamma-butyrobetaine to L-carnitine | Sus scrofa |