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Literature summary for 1.14.11.1 extracted from
- Uncoupling in the gamma-butyrobetaine hydroxylase reaction by D- and L-carnitine (1982), Biochem. Biophys. Res. Commun., 107, 518-524.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-carnitine | uncoupling agent | Pseudomonas sp. |  |
| DL-carnitine | uncouples the decarboxylation from the hydroxylation, mammalian enzyme | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.25 | - |
2-oxoglutarate | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| cytoplasm | - |
Pseudomonas sp. | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | requirement | Homo sapiens | |
| Fe2+ | requirement | Pseudomonas sp. | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Pseudomonas sp. | - |
AK1 | - |
| Pseudomonas sp. AK1 | - |
AK1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.162 | - |
human kidney | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 | - |
Homo sapiens | 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 | - |
? | |
| 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 | - |
Pseudomonas sp. | 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 | - |
? | |
| 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 | - |
Pseudomonas sp. AK1 | 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 | - |
? | |
| additional information | L-carnithine is an uncoupler | Homo sapiens | ? | - |
? | |
| additional information | L-carnithine is an uncoupler | Pseudomonas sp. | ? | - |
? | |
| additional information | L-carnithine is an uncoupler | Pseudomonas sp. AK1 | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Pseudomonas sp. |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
12 min half-life | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ascorbate | - |
Homo sapiens | |
| ascorbate | - |
Pseudomonas sp. | |
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Release 2023.1 (January 2023)
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