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Literature summary for 1.13.12.7 extracted from

  • Lee, R.T.; Denburg, J.L.; McElroy, W.D.
    Substrate-binding properties of firefly luciferase. II. ATP-binding site (1970), Arch. Biochem. Biophys., 141, 38-52.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3',5'-cyclic AMP
-
Photinus pyralis
ATP uncomplexed ATP is a competitive inhibitor with respect to MgATP2- complex Photinus pyralis
dAMP
-
Photinus pyralis
dATP
-
Photinus pyralis
MgATP2-
-
Photinus pyralis
phosphate
-
Photinus pyralis
ribose-5-phosphate
-
Photinus pyralis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
MgATP2-
-
Photinus pyralis

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+
-
Photinus pyralis
Mg2+ necessary for the activation step Photinus pyralis
Mn2+ influences the interaction with triazine dyes Photinus pyralis
additional information Ba2+ inactivates and Hg2+ is inhibitor Photinus pyralis
additional information activity in decreasing order: Mn2+, Mg2+, Co2+/Zn2+/Fe2+, Cd2+, Ni2+, Ca2+, Sr2+ Photinus pyralis

Organism

Organism UniProt Comment Textmining
Photinus pyralis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxyATP + Photinus luciferin
-
Photinus pyralis oxidized Photinus luciferin + CO2 + H2O + AMP + diphosphate + hv
-
?
luciferin + MgATP2-
-
Photinus pyralis AMP + diphosphate
-
?
Photinus luciferin + O2 + ATP the true substrate is MgATP2- Photinus pyralis oxidized Photinus luciferin + CO2 + H2O + AMP + diphosphate + hv
-
?

Subunits

Subunits Comment Organism
dimer two non identical subunits Photinus pyralis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.3
-
phosphate
-
Photinus pyralis
0.34
-
ribose-5-phosphate
-
Photinus pyralis
0.7
-
dATP
-
Photinus pyralis
0.9
-
dAMP
-
Photinus pyralis
0.9
-
3',5'-cyclic AMP
-
Photinus pyralis
1
-
MgATP2-
-
Photinus pyralis