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Literature summary for 1.13.11.80 extracted from

  • Tseng, C.C.; Vaillancourt, F.H.; Bruner, S.D.; Walsh, C.T.
    DpgC is a metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase in the vancomycin biosynthetic pathway (2004), Chem. Biol., 11, 1195-1203.
    View publication on PubMed
Search for more literature for 1.13.11.80

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 Amycolatopsis orientalis

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metal-free enzyme Amycolatopsis orientalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(3,5-dihydroxyphenyl)acetyl-CoA + O2 Amycolatopsis orientalis the enzyme from the Actinobacterium Streptomyces toyocaensis is involved in the biosynthesis of (3,5-dihydroxyphenyl)glycine, a nonproteinogenic amino acid monomer in the glycopeptide antibiotic vancomycin (3,5-dihydroxyphenyl)glyoxylate + CoA
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 ?

Organism

Organism UniProt Comment Textmining
Amycolatopsis orientalis G4V4T6
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-

Purification (Commentary)

Purification (Comment) Organism
-
 Amycolatopsis orientalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3,5-dihydroxyphenyl)acetyl-CoA + O2 the enzyme from the Actinobacterium Streptomyces toyocaensis is involved in the biosynthesis of (3,5-dihydroxyphenyl)glycine, a nonproteinogenic amino acid monomer in the glycopeptide antibiotic vancomycin Amycolatopsis orientalis (3,5-dihydroxyphenyl)glyoxylate + CoA
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 ?
(3,5-dihydroxyphenyl)acetyl-CoA + O2
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 Amycolatopsis orientalis (3,5-dihydroxyphenyl)glyoxylate + CoA
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 ?

Synonyms

Synonyms Comment Organism
DpgC
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 Amycolatopsis orientalis

Cofactor

Cofactor Comment Organism Structure
additional information cofactor-free enzyme Amycolatopsis orientalis

General Information

General Information Comment Organism
physiological function the enzyme from the actinobacterium Streptomyces toyocaensis is involved in the biosynthesis of (3,5-dihydroxyphenyl)glycine, a nonproteinogenic amino acid monomer in the glycopeptide antibiotic vancomycin Amycolatopsis orientalis