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Literature summary for 1.13.11.71 extracted from

  • Gong, X.; Marisiddaiah, R.; Zaripheh, S.; Wiener, D.; Rubin, L.P.
    Mitochondrial beta-carotene 9',10' oxygenase modulates prostate cancer growth via NF-kappaB inhibition a lycopene-independent function (2016), Mol. Cancer Res., 14, 966-975 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-beta-carotene + O2 Homo sapiens
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all-trans-10'-apo-beta-carotenal + beta-ionone
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYV7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
Homo sapiens
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epithelium
-
Homo sapiens
-
LNCaP cell
-
Homo sapiens
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LNCaP-C4-2 cell
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Homo sapiens
-
additional information expression of the genes bco1 and bco2 overlaps in the human gastrointestinal tract, but gene bco2, additionally, is expressed in several tissues neither known to be sensitive to vitamin A deficiency nor to express gene bco1 Homo sapiens
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PC-3 cell
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Homo sapiens
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prostate epithelium Homo sapiens
-
prostate cancer cell expression of the bco2 gene is dramatically decreased in prostate cancer tissue and in a range of prostate cancer cell lines as compared with nonneoplastic prostate tissue and normal prostatic epithelial cells, respectively. DNA methyltransferase inhibition induces bco2 expression in prostate cancer cells Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-beta-carotene + O2
-
Homo sapiens all-trans-10'-apo-beta-carotenal + beta-ionone
-
?

Synonyms

Synonyms Comment Organism
BCO2
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Homo sapiens
beta-carotene 9',10' oxygenase
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of the bco2 gene is dramatically decreased in prostate cancer tissue and in a range of prostate cancer cell lines as compared with nonneoplastic prostate tissue and normal prostatic epithelial cells, respectively. Inhibition of DNA methyltransferase activity restores bco2 expression in prostate cancer cell lines tested down
Homo sapiens treatment with lycopene or its metabolite, apo-10-lycopenal, increases bco2 expression and reduces cell proliferation in androgen-sensitive cell lines, but lycopene neither alters bco2 expression nor cell growth in androgen-resistant cells up

General Information

General Information Comment Organism
malfunction epigenetic loss of BCO2 expression is associated with prostate cancer progression, molecular mechanisms of BCO2 actions in prostate cancer, overview Homo sapiens
metabolism the enzyme is imortant in lycopene metabolism Homo sapiens
physiological function mitochondrial beta-carotene-9',10'-oxygenase modulates prostate cancer growth via NF-kappaB inhibition in a lycopene-independent manner. Restoring bco2 expression in prostate cancer cells inhibits cell proliferation and colony formation, irrespective of lycopene exposure. Exogenous expression of either wild-type BCO2 or a mutant (enzymatically inactive) BCO2 in prostate cancer cells reduces NF-kappaB activity and decreases NF-kappaB nuclear translocation and DNA binding. BCO2 has functions that are independent of its enzymatic role in lycopene metabolism. BCO2 is a tumor suppressor in prostate cancer. BCO2-mediated inhibition of NF-kappaB signaling implies BCO2 status is important in prostate cancer progression Homo sapiens