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Literature summary for 1.13.11.69 extracted from

  • Bruno, M.; Vermathen, M.; Alder, A.; Wuest, F.; Schaub, P.; van der Steen, R.; Beyer, P.; Ghisla, S.; Al-Babili, S.
    Insights into the formation of carlactone from in-depth analysis of the CCD8-catalyzed reactions (2017), FEBS Lett., 591, 792-800 .
    View publication on PubMed
Search for more literature for 1.13.11.69

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ involved in catalysis, mechanism overview Pisum sativum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
9-cis-10'-apo-beta-carotenal + 2 O2 Pisum sativum
-
 carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal
-
 ?

Organism

Organism UniProt Comment Textmining
Pisum sativum
-
-
-

Reaction

Reaction Comment Organism Reaction ID
9-cis-10'-apo-beta-carotenal + 2 O2 = carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal proposed mechanism of 9-cis-beta-apo-10'-carotenal conversion into carlactone, overview Pisum sativum
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
9-cis-10'-apo-beta-carotenal + 2 O2
-
 Pisum sativum carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal
-
 ?

Synonyms

Synonyms Comment Organism
carotenoid cleavage dioxygenase 8
-
 Pisum sativum
CCD8
-
 Pisum sativum
PsCCD8
-
 Pisum sativum

General Information

General Information Comment Organism
physiological function the carotenoid cleavage dioxygenase 8, CCD8, catalyzes a series of reactions and molecular rearrangements for biosynthesis of strigolactones, a class of phytohormones synthesized from carotenoids via carlactone. The complex structure of carlactone is not easily deducible from its precursor 9-cis-beta-apo-10'-carotenal, a cis-configured beta-carotene cleavage product. Carlactone and (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal, and reaction intermediates structure analysis by LC-MS and NMR, overview Pisum sativum