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Literature summary for 1.13.11.63 extracted from

  • Kim, Y.K.; Zuccaro, M.V.; Costabile, B.K.; Rodas, R.; Quadro, L.
    Tissue- and sex-specific effects of beta-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice (2015), Arch. Biochem. Biophys., 572, 11-18 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.63

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-carotene + O2 Mus musculus
-
 2 all-trans-retinal
-
 ?
beta-carotene + O2 Mus musculus C57BL/6
-
 2 all-trans-retinal
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JJS6
-
-
Mus musculus C57BL/6 Q9JJS6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Mus musculus
-
brain adult and embryonic, very low Bco1 expression level Mus musculus
-
embryo
-
 Mus musculus
-
eye
-
 Mus musculus
-
heart
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver adult and embryonic, high Bco1 expression level Mus musculus
-
lung
-
 Mus musculus
-
mammary gland
-
 Mus musculus
-
additional information retinoid levels in the developing liver and brain at mid-gestation, overview. BCO1-/- and wild-type female mice reveal a statistically significant decrease in retinol content in the heart, pancreas, spleen, eye and adipose tissue of the knockout females. Retinol concentrations are greater in the lungs of the BCO1-/- females compared to wild-type Mus musculus
-
pancreas
-
 Mus musculus
-
spleen
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-carotene + O2
-
 Mus musculus 2 all-trans-retinal
-
 ?
beta-carotene + O2
-
 Mus musculus C57BL/6 2 all-trans-retinal
-
 ?

Synonyms

Synonyms Comment Organism
BCO1
-
 Mus musculus
beta-carotene 15,15' oxygenase
-
 Mus musculus
beta-carotene 15,15'-oxygenase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction deficiency of BCO1 in the liver does not significantly affect retinol or retinyl ester concentrations compared to the wild-type group, even though retinyl ester levels tend to be lower in the absence of BCO1. BCO1-/- and wild-type female mice reveal a statistically significant decrease in retinol content in the heart, pancreas, spleen, eye and adipose tissue of the knockout females. Retinol concentrations are greater in the lungs of the BCO1-/- females compared to wild-type Mus musculus