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Literature summary for 1.13.11.63 extracted from

  • Lee, S.A.; Jiang, H.; Trent, C.M.; Yuen, J.J.; Narayanasamy, S.; Curley, R.W.; Harrison, E.H.; Goldberg, I.J.; Maurer, M.S.; Blaner, W.S.
    Cardiac dysfunction in beta-carotene-15,15-dioxygenase-deficient mice is associated with altered retinoid and lipid metabolism (2014), Am. J. Physiol. Heart Circ. Physiol., 307, H1675-H1684 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-carotene + O2 Mus musculus
-
 2 all-trans-retinal
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JJS6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart beta-carotene-15,15'-dioxygenase (BCO1) protein is not expressed in adult hearts of male wild-type mice Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-carotene + O2
-
 Mus musculus 2 all-trans-retinal
-
 ?

Synonyms

Synonyms Comment Organism
BCO1
-
 Mus musculus
beta-carotene-15,15'-dioxygenase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction cardiac dysfunction in beta-carotene-15,15-dioxygenase-deficient mice is associated with altered retinoid and lipid metabolism. Bco1-/- mice show an increase in heart levels of retinol, nonesterified fatty acids, and ceramides and a decrease in heart triglycerides. These lipid changes are accompanied by elevations in levels of genes important to retinoid metabolism, specifically retinol dehydrogenase 10 and retinol-binding protein 4, as well as genes involved in lipid metabolism, including peroxisome proliferator-activated receptor-gamma, lipoprotein lipase, Cd36, stearoyl-CoA desaturase 1, and fatty acid synthase. The mutant mice show compromised heart function. But the total absence of Bco1 does not substantially affect beta-apo-carotenoid concentrations in the heart. Phenotype, overview Mus musculus
physiological function dietary carotenoids like beta-carotene are converted within the body either to retinoid, via beta-carotene-15,15'-dioxygenase (BCO1), or to beta-apo-carotenoids, via beta-carotene-9',10'-oxygenase 2. Some beta-apo-carotenoids are potent antagonists of retinoic acid receptor (RAR)-mediated transcriptional regulation, which is required to ensure normal heart development and functions. BCO1 modulates heart metabolism and function, possibly by altering levels of cofactors required for the actions of nuclear hormone receptors Mus musculus