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Literature summary for 1.13.11.63 extracted from
- Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15'-dioxygenase (2001), J. Biol. Chem., 276, 6560-6565.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Mus musculus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.06 | - |
beta-carotene | pH 8.0, 37°C | Mus musculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 63000 | - |
x * 63859, calculated, x * 63000, SDS-PAGE | Mus musculus |
| 63859 | - |
x * 63859, calculation from nucleotide sequence | Mus musculus |
| 63859 | - |
x * 63859, calculated, x * 63000, SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-carotene + O2 | Mus musculus | crucial enzyme in development and metabolism that governs the de novo entry of vitamin A from plant-derived precursors, enzyme may play a critical role in gastrulation | retinal | - |
? | |
| beta-carotene + O2 | Mus musculus | enzyme may play a critical role in gastrulation | retinal | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9JJS6 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | mRNA is abundant at embryonic day 7, with lower expression at embryonic days 11, 13 and 15 | Mus musculus | - |
| intestine | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| small intestine | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-carotene + O2 | - |
Mus musculus | retinal | - |
? | |
| beta-carotene + O2 | crucial enzyme in development and metabolism that governs the de novo entry of vitamin A from plant-derived precursors, enzyme may play a critical role in gastrulation | Mus musculus | retinal | - |
? | |
| beta-carotene + O2 | enzyme may play a critical role in gastrulation | Mus musculus | retinal | - |
? | |
| beta-carotene + O2 | - |
Mus musculus | 2 all-trans-retinal | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 63859, calculation from nucleotide sequence | Mus musculus |
| ? | x * 63859, calculated, x * 63000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-carotene dioxygenase 1 | - |
Mus musculus |
| beta-CD | - |
Mus musculus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0001 | - |
beta-carotene | - |
Mus musculus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | mRNA is abundant at embryonic day 7, with lower expression at embryonic days 11, 13, and 15 | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | crucial enzyme in development and metabolism that governs the de novo entry of vitamin A from plant-derived precursors | Mus musculus |
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