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Literature summary for 1.13.11.6 extracted from

  • Yang, Y.; Liu, F.; Liu, A.
    Adapting to oxygen 3-hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities (2018), J. Biol. Chem., 293, 10415-10424 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.6

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop method Cupriavidus metallidurans

Protein Variants

Protein Variants Comment Organism
I142A the variant cannot form a closed conformation and has a substantially higher Km for O2 than wild-type enzyme Cupriavidus metallidurans
I142P the variant cannot form a closed conformation and has a substantially higher Km for O2 than wild-type enzyme Cupriavidus metallidurans
N27A the variant cannot form a closed conformation and has a substantially higher Km for O2 than wild-type enzyme Cupriavidus metallidurans

Metals/Ions

Metals/Ions Comment Organism Structure
Iron enhanced hydrophobicity at the iron center results from the concerted loop movements after the binding of the primary substrate Cupriavidus metallidurans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxyanthranilate + O2 Cupriavidus metallidurans
-
 2-amino-3-carboxymuconate semialdehyde
-
 ?
3-hydroxyanthranilate + O2 Cupriavidus metallidurans ATCC 43123
-
 2-amino-3-carboxymuconate semialdehyde
-
 ?

Organism

Organism UniProt Comment Textmining
Cupriavidus metallidurans Q1LCS4
-
-
Cupriavidus metallidurans ATCC 43123 Q1LCS4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxyanthranilate + O2
-
 Cupriavidus metallidurans 2-amino-3-carboxymuconate semialdehyde
-
 ?
3-hydroxyanthranilate + O2 the enzyme employs loop dynamics to accommodate two substrates with disparate polarities Cupriavidus metallidurans 2-amino-3-carboxymuconate semialdehyde
-
 ?
3-hydroxyanthranilate + O2
-
 Cupriavidus metallidurans ATCC 43123 2-amino-3-carboxymuconate semialdehyde
-
 ?
3-hydroxyanthranilate + O2 the enzyme employs loop dynamics to accommodate two substrates with disparate polarities Cupriavidus metallidurans ATCC 43123 2-amino-3-carboxymuconate semialdehyde
-
 ?

Synonyms

Synonyms Comment Organism
HAO
-
 Cupriavidus metallidurans