Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.6 extracted from

  • Okuno, E.; Köhler, C.; Schwarcz, R.
    Rat 3-hydroxyanthranilic acid oxygenase: purification from the liver and immunocytochemical localization in the brain (1987), J. Neurochem., 49, 771-780.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003 0.0036 3-hydroxyanthranilic acid
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000 38000 gel filtration, SDS-PAGE, sucrose density gradient centrifugation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxyanthranilate + O2 Rattus norvegicus biosynthetic enzyme of the endogenous excitotoxin quinolinic acid 2-amino-3-carboxymuconate semialdehyde
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
pure liver enzyme, partielly purified brain enzyme Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain relatively small amounts Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [Āµmol/min/mg] Specific Activity Maximum [Āµmol/min/mg] Comment Organism
0.0003
-
brain Rattus norvegicus
0.0075
-
liver Rattus norvegicus
7.5
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxyanthranilate + O2
-
Rattus norvegicus 2-amino-3-carboxymuconate semialdehyde reacts spontaneously to quinolinic acid ?
3-hydroxyanthranilate + O2 biosynthetic enzyme of the endogenous excitotoxin quinolinic acid Rattus norvegicus 2-amino-3-carboxymuconate semialdehyde
-
?

Subunits

Subunits Comment Organism
monomer 1 * 37000-38000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5 7
-
Rattus norvegicus