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Literature summary for 1.13.11.6 extracted from
- Rat 3-hydroxyanthranilic acid oxygenase: purification from the liver and immunocytochemical localization in the brain (1987), J. Neurochem., 49, 771-780.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | 0.0036 | 3-hydroxyanthranilic acid | - |
Rattus norvegicus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 37000 | 38000 | gel filtration, SDS-PAGE, sucrose density gradient centrifugation | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxyanthranilate + O2 | Rattus norvegicus | biosynthetic enzyme of the endogenous excitotoxin quinolinic acid | 2-amino-3-carboxymuconate semialdehyde | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| pure liver enzyme, partielly purified brain enzyme | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | relatively small amounts | Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0003 | - |
brain | Rattus norvegicus |
| 0.0075 | - |
liver | Rattus norvegicus |
| 7.5 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxyanthranilate + O2 | - |
Rattus norvegicus | 2-amino-3-carboxymuconate semialdehyde | reacts spontaneously to quinolinic acid | ? | |
| 3-hydroxyanthranilate + O2 | biosynthetic enzyme of the endogenous excitotoxin quinolinic acid | Rattus norvegicus | 2-amino-3-carboxymuconate semialdehyde | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 37000-38000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 7 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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