Literature summary for 1.13.11.6 extracted from

Wang, Y.; Liu, K.F.; Yang, Y.; Davis, I.; Liu, A.
Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens (2020), Proc. Natl. Acad. Sci. USA, 117, 19720-19730 .

Search for more literature for 1.13.11.6

Crystallization (Commentary)

Crystallization (Comment)	Organism
seven catalytic intermediates are kinetically and structurally resolved in the crystalline state, and each accompanies protein conformational changes at the active site. Among them, a monooxygenated, seven-membered lactone intermediate as a monodentate ligand of the iron center at 1.59 A resolution is captured, which presumably corresponds to a substrate-based radical species observed by EPR using a slurry of small-sized single crystals. Other structural snapshots determined at around 2.0 A resolution include monodentate and subsequently bidentate coordinated substrate, superoxo, alkylperoxo, and two metal-bound enol tautomers of the unstable dioxygenase product	Cupriavidus metallidurans

Crystallization (Comment)

Organism

seven catalytic intermediates are kinetically and structurally resolved in the crystalline state, and each accompanies protein conformational changes at the active site. Among them, a monooxygenated, seven-membered lactone intermediate as a monodentate ligand of the iron center at 1.59 A resolution is captured, which presumably corresponds to a substrate-based radical species observed by EPR using a slurry of small-sized single crystals. Other structural snapshots determined at around 2.0 A resolution include monodentate and subsequently bidentate coordinated substrate, superoxo, alkylperoxo, and two metal-bound enol tautomers of the unstable dioxygenase product

Cupriavidus metallidurans

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	nonheme iron-based enzyme	Cupriavidus metallidurans

Organism

Organism	UniProt	Comment	Textmining
Cupriavidus metallidurans	Q1LCS4	-	-
Cupriavidus metallidurans ATCC 43123	Q1LCS4	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-hydroxyanthranilate + O2	-	Cupriavidus metallidurans	2-amino-3-carboxymuconate semialdehyde	-	?
3-hydroxyanthranilate + O2	-	Cupriavidus metallidurans ATCC 43123	2-amino-3-carboxymuconate semialdehyde	-	?

Synonyms

Synonyms	Comment	Organism
HAO	-	Cupriavidus metallidurans

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Release 2023.1 (January 2023)