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Literature summary for 1.13.11.54 extracted from

  • Quintero-Troconis, E.; Buelvas, N.; Carrasco-Lopez, C.; Domingo-Sananes, M.; Gonzalez-González, L.; Ramirez-Molina, R.; Osorio, L.; Lobo-Rojas, A.; Caceres, A.; Michels, P.; Acosta, H.; Quinones, W.; Concepcion, J.
    Enolase from Trypanosoma cruzi is inhibited by its interaction with metallocarboxypeptidase-1 and a putative acireductone dioxygenase (2018), Biochim. Biophys. Acta Proteins Proteom., 1866, 651-660 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Trypanosoma cruzi 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
gel filtration Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 Trypanosoma cruzi
-
4-(methylsulfanyl)-2-oxobutanoate + formate
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi A0A2V2XFM8 and A0A2V2VIR7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2
-
Trypanosoma cruzi 4-(methylsulfanyl)-2-oxobutanoate + formate
-
?
additional information the enzyme has two different catalytic domains, its N-terminal half related to acireductone dioxygenase and its C-terminal half related to thioredoxin-related protein of 14 kDa. Enolase from Trypanosoma cruzi is inhibited by its interaction with metallocarboxypeptidase-1 and the enzyme Trypanosoma cruzi ?
-
-

Subunits

Subunits Comment Organism
monomer 1 * 40000, SDS-PAGE Trypanosoma cruzi
monomer 1 * 37600, calculated from amino acid sequence Trypanosoma cruzi

Synonyms

Synonyms Comment Organism
ARDp
-
Trypanosoma cruzi

pI Value

Organism Comment pI Value Maximum pI Value
Trypanosoma cruzi calculated from amino acid sequence
-
5.7