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Literature summary for 1.13.11.52 extracted from

  • Zhao, H.; Sun, P.; Guo, W.; Wang, Y.; Zhang, A.; Meng, L.; Ding, C.
    Discovery of indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitors based on ortho-naphthaquinone-containing natural product (2019), Molecules, 24, 1059 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.52

Inhibitors

Inhibitors Comment Organism Structure
1,6,6-trimethyl-10,11-dioxo-2-(thiophen-3-yl)-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate 0.02 mM, 29.3% inhibition Homo sapiens
1,6,6-trimethyl-10,11-dioxo-2-phenyl-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate 0.02 mM, 21.5% inhibition Homo sapiens
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 1,3-thiazole-2-carboxylate
-
 Homo sapiens
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl acetate
-
 Homo sapiens
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl benzoate 0.02 mM, 54.5% inhibition Homo sapiens
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl cyclohexanecarboxylate 0.02 mM, 48.0% inhibition Homo sapiens
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl cyclopropanecarboxylate
-
 Homo sapiens
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl furan-3-carboxylate
-
 Homo sapiens
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl hydroxyacetate
-
 Homo sapiens
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate
-
 Homo sapiens
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl thiophene-2-carboxylate 0.02 mM, 60.4% inhibition Homo sapiens
1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione 0.02 mM, 23.1% inhibition Homo sapiens
1,6,6-trimethyl-6,7-dihydrophenanthro[1,2-b]furan-10,11-dione 0.02 mM, 61.2% inhibition Homo sapiens
1,6,6-trimethylphenanthro[1,2-b]furan-7,10,11(6H)-trione
-
 Homo sapiens
1,6,6-trimethylphenanthro[1,2-b]furan-9,10,11(6H)-trione 0.02 mM, 52.7% inhibition Homo sapiens
1-(hydroxymethyl)-6,6-dimethylphenanthro[1,2-b]furan-7,10,11(6H)-trione
-
 Homo sapiens
1-(hydroxymethyl)-6,6-dimethylphenanthro[1,2-b]furan-9,10,11(6H)-trione 0.02 mM, 68% inhibition Homo sapiens
7-hydroxy-1,6,6-trimethyl-6,7-dihydrophenanthro[1,2-b]furan-10,11-dione
-
 Homo sapiens
9-hydroxy-1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione
-
 Homo sapiens
epacadostat
-
 Homo sapiens
ethyl 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl (2E)-but-2-enedioate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14902
-
-

Synonyms

Synonyms Comment Organism
IDO-1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000086
-
 pH 6.5, 37°C Homo sapiens epacadostat
0.00037
-
 37°C, pH 6.5 Homo sapiens 1-(hydroxymethyl)-6,6-dimethylphenanthro[1,2-b]furan-7,10,11(6H)-trione
0.00084
-
 37°C, pH 6.5 Homo sapiens 1,6,6-trimethylphenanthro[1,2-b]furan-7,10,11(6H)-trione
0.00274
-
 37°C, pH 6.5 Homo sapiens 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl hydroxyacetate
0.00283
-
 37°C, pH 6.5 Homo sapiens 9-hydroxy-1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione
0.0031
-
 37°C, pH 6.5 Homo sapiens 7-hydroxy-1,6,6-trimethyl-6,7-dihydrophenanthro[1,2-b]furan-10,11-dione
0.00372
-
 37°C, pH 6.5 Homo sapiens 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl acetate
0.0046
-
 37°C, pH 6.5 Homo sapiens 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl furan-3-carboxylate
0.00472
-
 37°C, pH 6.5 Homo sapiens 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate
0.00571
-
 37°C, pH 6.5 Homo sapiens 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 1,3-thiazole-2-carboxylate
0.00705
-
 37°C, pH 6.5 Homo sapiens 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl cyclopropanecarboxylate
0.00747
-
 37°C, pH 6.5 Homo sapiens ethyl 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl (2E)-but-2-enedioate
0.0215
-
 37°C, pH 6.5 Homo sapiens 1,6,6-trimethyl-10,11-dioxo-2-phenyl-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate
0.0293
-
 37°C, pH 6.5 Homo sapiens 1,6,6-trimethyl-10,11-dioxo-2-(thiophen-3-yl)-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate

General Information

General Information Comment Organism
drug target as an immunosuppressive enzyme, indoleamine 2,3-dioxygenase 1 is considered a promising target for oncology immunotherapy Homo sapiens