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Literature summary for 1.13.11.52 extracted from

  • Kaellberg, E.; Wikstroem, P.; Bergh, A.; Ivars, F.; Leanderson, T.
    Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model (2010), Prostate, 70, 1461-1470.
    View publication on PubMed
Search for more literature for 1.13.11.52

Application

Application Comment Organism
medicine systemic IDO activity, determined as the kynurenine/tryptophan ratio in serum, correlates with the presence of palpable tumor. IDO mediates immune suppression in the early stages of prostate cancer progression. IDO expression in the tumor tissue is irrelevant for transgenic adenocarcinoma of mouse prostate tumor incidence Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Mus musculus
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:CD31+ cell
-
 Mus musculus
-
culture condition:CD31- cell
-
 Mus musculus
-
lymph node
-
 Mus musculus
-
prostate
-
 Mus musculus
-
serum
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Mus musculus N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO
-
 Mus musculus