Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methyl-D-tryptophan | the isomer is more effective in inhibiting IDO than 1-methyl-L-tryptophan | Homo sapiens | |
1-methyl-D-tryptophan | the isomer is more effective in inhibiting IDO than 1-methyl-L-tryptophan | Mus musculus | |
1-methyl-DL-tryptophan | - |
Homo sapiens | |
1-methyl-DL-tryptophan | - |
Mus musculus | |
1-methyl-L-tryptophan | the isomer is less effective in inhibiting IDO than 1-methyl-D-tryptophan | Homo sapiens | |
1-methyl-L-tryptophan | the isomer is less effective in inhibiting IDO than 1-methyl-D-tryptophan | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Mus musculus | - |
N-formyl-L-kynurenine | - |
? | |
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Mus musculus | - |
colon | - |
Homo sapiens | - |
culture condition:CD103+ cell | - |
Mus musculus | - |
culture condition:CD103+ cell | - |
Homo sapiens | - |
duodenum | - |
Mus musculus | - |
duodenum | - |
Homo sapiens | - |
ileum | IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level | Mus musculus | - |
ileum | IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level | Homo sapiens | - |
intestine | IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level | Mus musculus | - |
intestine | IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level | Homo sapiens | - |
jejunum | IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level | Mus musculus | - |
jejunum | IDO is highly expressed throughout the intestine with a marked presence in the jejunum and ileum both at the RNA and protein level | Homo sapiens | - |
additional information | IDO is not detected in CD103- gut dendritic cells and in spleen | Mus musculus | - |
additional information | IDO is not detected in CD103- gut dendritic cells and in spleen | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | - |
Mus musculus | N-formyl-L-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Mus musculus |
IDO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Mus musculus | |
heme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | IDO inhibition significantly affects the ability of CD103+ dendritic cells to promote conversion of naive T cells into Foxp3+Tregs while the ability of CD103- cells is unaffected. IDO inhibition impinges on the development of oral tolerance | Mus musculus |
malfunction | IDO inhibition significantly affects the ability of CD103+ denxritic cells to promote conversion of naive T cells into Foxp3+Tregs while the ability of CD103- cells is unaffected. IDO inhibition impinges on the development of oral tolerance | Homo sapiens |
physiological function | indoleamine 2,3-dioxygenase is an enzyme involved in tryptophan catabolism with immunosuppressive effects influencing T regulatory/T effector cell balance and oral tolerance induction | Mus musculus |
physiological function | indoleamine 2,3-dioxygenase is an enzyme involved in tryptophan catabolism with immunosuppressive effects influencing T regulatory/T effector cell balance and oral tolerance induction | Homo sapiens |