Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
culture condition:CD8+ cell | - |
Homo sapiens | - |
peripheral blood mononuclear cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | TLR9 ligand CpG, soluble CTLA4 or interferon-gamma induce IDO expression | up |
General Information | Comment | Organism |
---|---|---|
physiological function | IDO is an immunoregulatory enzyme that is implicated in suppressing T-cell immunity in normal and pathological settings. IDO5-specific T cells are specifically able to kill IDO-expressing cells. IDO-specific T cells boost viral immunity | Homo sapiens |