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Literature summary for 1.13.11.52 extracted from

  • Kumar, S.; Jaller, D.; Patel, B.; LaLonde, J.M.; DuHadaway, J.B.; Malachowski, W.P.; Prendergast, G.C.; Muller, A.J.
    Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase (2008), J. Med. Chem., 51, 4968-4977.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.52

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-benzyl-5-phenyl-1H-imidazole
-
 Homo sapiens
2-(1H-imidazol-4-yl)benzene-1,3-diol
-
 Homo sapiens
2-(1H-imidazol-4-yl)benzenethiol
-
 Homo sapiens
2-(1H-imidazol-4-yl)phenol
-
 Homo sapiens
2-(1H-pyrazol-3-yl)phenol
-
 Homo sapiens
3-(1H-imidazol-4-yl)benzaldehyde
-
 Homo sapiens
3-(1H-imidazol-4-yl)benzenethiol
-
 Homo sapiens
3-(1H-imidazol-4-yl)benzonitrile
-
 Homo sapiens
3-(1H-imidazol-4-yl)phenol
-
 Homo sapiens
3-(4H-imidazol-4-yl)benzenethiol
-
 Homo sapiens
3-phenylpyridine
-
 Homo sapiens
4-(1H-imidazol-4-yl)phenol
-
 Homo sapiens
4-(2,6-dimethoxyphenyl)-1H-imidazole
-
 Homo sapiens
4-(2-(methylthio)phenyl)-1H-imidazole
-
 Homo sapiens
4-(2-fluorophenyl)-1H-imidazole
-
 Homo sapiens
4-(3-(methylthio)phenyl)-1H-imidazole
-
 Homo sapiens
4-(3-fluorophenyl)-1H-imidazole
-
 Homo sapiens
4-(4-(methylthio)phenyl)-1H-imidazole
-
 Homo sapiens
4-(4-fluorophenyl)-1H-imidazole
-
 Homo sapiens
4-(thiophen-2-yl)-1H-imidazole
-
 Homo sapiens
4-fluoro-2-(1H-pyrazol-3-yl)phenol
-
 Homo sapiens
4-phenylimidazole
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.042
-
 L-tryptophan
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14902
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Homo sapiens N-formylkynurenine
-
 ?

Synonyms

Synonyms Comment Organism
indoleamine 2,3-dioxygenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0048
-
 3-(4H-imidazol-4-yl)benzenethiol
-
 Homo sapiens
0.0053
-
 3-(1H-imidazol-4-yl)benzenethiol
-
 Homo sapiens
0.0089
-
 2-(1H-imidazol-4-yl)phenol
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0048
-
-
 Homo sapiens 2-(1H-imidazol-4-yl)phenol
0.0053
-
-
 Homo sapiens 2-(1H-imidazol-4-yl)benzene-1,3-diol
0.0076
-
-
 Homo sapiens 3-(1H-imidazol-4-yl)benzenethiol
0.0077
-
-
 Homo sapiens 3-(4H-imidazol-4-yl)benzenethiol
0.025
-
-
 Homo sapiens 2-(1H-imidazol-4-yl)benzenethiol
0.026
-
-
 Homo sapiens 4-fluoro-2-(1H-pyrazol-3-yl)phenol
0.032
-
-
 Homo sapiens 1-benzyl-5-phenyl-1H-imidazole
0.035
-
-
 Homo sapiens 2-(1H-pyrazol-3-yl)phenol
0.038
-
-
 Homo sapiens 4-(2-(methylthio)phenyl)-1H-imidazole
0.041
-
-
 Homo sapiens 3-(1H-imidazol-4-yl)benzonitrile
0.048
-
-
 Homo sapiens 4-phenylimidazole
0.06
-
-
 Homo sapiens 4-(3-fluorophenyl)-1H-imidazole
0.073
-
-
 Homo sapiens 4-(3-(methylthio)phenyl)-1H-imidazole
0.123
-
-
 Homo sapiens 4-(4-fluorophenyl)-1H-imidazole
0.161
-
-
 Homo sapiens 3-phenylpyridine
0.179
-
-
 Homo sapiens 4-(2-fluorophenyl)-1H-imidazole
0.209
-
-
 Homo sapiens 4-(4-(methylthio)phenyl)-1H-imidazole
0.365
-
-
 Homo sapiens 3-(1H-imidazol-4-yl)phenol
0.422
-
-
 Homo sapiens 4-(thiophen-2-yl)-1H-imidazole
0.734
-
-
 Homo sapiens 4-(2,6-dimethoxyphenyl)-1H-imidazole
0.825
-
-
 Homo sapiens 3-(1H-imidazol-4-yl)benzaldehyde
1.2
-
-
 Homo sapiens 4-(1H-imidazol-4-yl)phenol