Literature summary for 1.13.11.52 extracted from

Basran, J.; Rafice, S.A.; Chauhan, N.; Efimov, I.; Cheesman, M.R.; Ghamsari, L.; Raven, E.L.
A kinetic, spectroscopic, and redox study of human tryptophan 2,3-dioxygenase (2008), Biochemistry, 47, 4752-4760.

Search for more literature for 1.13.11.52

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli as a full-length, C-terminal hexahistidine fusion protein	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.006	-	5-fluoro-tryptophan	-	Homo sapiens
0.007	-	L-tryptophan	-	Homo sapiens
0.017	-	5-hydroxy-tryptophan	-	Homo sapiens
0.098	-	5-methyl-tryptophan	-	Homo sapiens
0.222	-	L-tryptophan	-	Homo sapiens
0.36	-	5-fluoro-tryptophan	-	Homo sapiens
1.57	-	D-tryptophan	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Homo sapiens	P48775	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-fluoro-tryptophan + O2	-	Homo sapiens	4-(2-amino-5-fluorophenyl)-2-(formylamino)-4-oxobutanoic acid	-	?
5-fluoro-tryptophan + O2	-	Homo sapiens	?	-	?
5-hydroxy-tryptophan + O2	-	Homo sapiens	4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid	-	?
5-methyl-tryptophan + O2	-	Homo sapiens	4-(2-amino-5-methylphenyl)-2-(formylamino)-4-oxobutanoic acid	-	?
D-tryptophan + O2	-	Homo sapiens	N-formyl-D-kynurenine	-	?
L-tryptophan + O2	-	Homo sapiens	N-formyl-L-kynurenine	-	?
L-tryptophan + O2	no activity with D-tryptophan	Homo sapiens	N-formyl-L-kynurenine	-	?
additional information	no activity with tryptophanol, indole-3-propionic acid, tryptamine, N-methyl-Trp	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
hIDO	-	Homo sapiens
hTDO	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.025	-	5-hydroxy-tryptophan	-	Homo sapiens
0.18	-	5-fluoro-tryptophan	-	Homo sapiens
0.76	-	5-fluoro-tryptophan	-	Homo sapiens
1.4	-	L-tryptophan	-	Homo sapiens
3.78	-	5-methyl-tryptophan	-	Homo sapiens
3.93	-	D-tryptophan	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)