Activating Compound | Comment | Organism | Structure |
---|---|---|---|
alpha-interferon | induces IDO expression in monocytes | Homo sapiens | |
beta-interferon | induces IDO expression in monocytes | Homo sapiens | |
gamma-interferon | induces IDO expression | Mus musculus | |
gamma-interferon | induces IDO expression | Homo sapiens | |
gamma-interferon | induces IDO expression | Oryctolagus cuniculus | |
hyperoxia | induces IDO expression in the lung | Oryctolagus cuniculus | |
lipopolysaccharide | induces IDO expression in monocytes | Homo sapiens | |
lipopolysaccharide | induces IDO expression in the lung | Oryctolagus cuniculus | |
paraquat | induces IDO expression in the lung | Oryctolagus cuniculus |
Application | Comment | Organism |
---|---|---|
medicine | plays a role in the antiparasitic defense in humans, inhibits the growth of tumor cell lines in vitro, inhibits T lymphocyte proliferation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-Methyltryptophan | treatment of pregnant mice result in rapid T-cell-induces rejection of allogeneic concepti | Mus musculus | |
dexamethasone | inhibits IDO activity in brain and lung after systemic pokeweed mitogen administration and brains of mice suffering from malaria | Mus musculus | |
dexamethasone | - |
Oryctolagus cuniculus | |
H2O2 | - |
Homo sapiens | |
H2O2 | - |
Mus musculus | |
interleukin-4 | - |
Homo sapiens | |
NO | - |
Homo sapiens | |
NO | inhibits the transcription of IDO in murine macrophages | Mus musculus | |
transforming growth factor-beta | inhibits expression in skin and synovial fibroblasts | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Mus musculus | - |
N-formyl-L-kynurenine | - |
? | |
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? | |
L-tryptophan + O2 | Oryctolagus cuniculus | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
pregnant | - |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
cerebrospinal fluid | from humans suffering from inflammatory neurological disorders exhibit increased IDO activity | Homo sapiens | - |
epididymis | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
lung | - |
Oryctolagus cuniculus | - |
lung | cancer bearing lung exhibits 20fold increase in IDO activity | Homo sapiens | - |
monocyte | induced by alpha-, beta- and gamma-interferon | Homo sapiens | - |
skin fibroblast | - |
Homo sapiens | - |
small intestine | - |
Mus musculus | - |
synovial fibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | - |
Mus musculus | N-formyl-L-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Oryctolagus cuniculus | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Mus musculus |
IDO | - |
Homo sapiens |
IDO | - |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | O2- | Mus musculus | |
additional information | O2- | Homo sapiens | |
additional information | O2- | Oryctolagus cuniculus |