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Literature summary for 1.13.11.52 extracted from
- Age-related nuclear cataract and indoleamine 2,3-dioxygenase-initiated tryptophan metabolism in the human lens (2003), Adv. Exp. Med. Biol., 527, 277-285.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | yellowing of the aged lens may be preventable by drug-induced suppression of IDO activity | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Trp + O2 | Homo sapiens | IDO is the first enzyme in UV-filter pathway. UV-filter biosynthesis is active even in aged lenses | L-formylkynurenine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lens | enzyme activity is detected in all lenses ranging from 26 to 80 years and there are no clear relationship of IDO activity with age | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Trp + O2 | IDO is the first enzyme in UV-filter pathway. UV-filter biosynthesis is active even in aged lenses | Homo sapiens | L-formylkynurenine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IDO | - |
Homo sapiens |
| indoleamine 2,3-dioxygenase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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