Literature summary for 1.13.11.52 extracted from

Dick, R.; Murray, B.P.; Reid, M.J.; Correia, M.A.
Structure-Function Relationships of Rat Hepatic Tryptophan 2,3-Dioxygenase: Identification of the Putative Heme-Ligating Histidine Residues (2001), Arch. Biochem. Biophys., 392, 71-78.

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Protein Variants

Protein Variants	Comment	Organism
H238A	mutant retains little or no heme, strong reduction of activity	Rattus norvegicus
H75A	mutant retains little or no heme, strong reduction of activity	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-Trp + O2	Rattus norvegicus	enzyme controls the physiological flux of Trp into both the serotonergic and kynureninic pathways	L-formylkynurenine	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Trp + O2	-	Rattus norvegicus	L-formylkynurenine	-	?
L-Trp + O2	enzyme controls the physiological flux of Trp into both the serotonergic and kynureninic pathways	Rattus norvegicus	L-formylkynurenine	-	?

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Release 2023.1 (January 2023)