Literature summary for 1.13.11.52 extracted from

Hissong, B.D.; Byrne, G.I.; Padilla, M.L.; Carlin, J.M.
Upregulation of interferon-induced indoleamine 2,3-dioxygenase in human macrophage cultures by lipopolysaccharide, muramyl tripeptide, and interleukin-1 (1995), Cell. Immunol., 160, 264-269.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-Trp + O2	Homo sapiens	lipopolysaccharide and muramyl tripeptide upregulate enzyme induction through a mechanism independent of interleukin 1alpha	L-formylkynurenine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	enzyme is induced in monocyte-derived macrophages treated with human recombinant interferon-beta or interferon gamma	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Trp + O2	-	Homo sapiens	L-formylkynurenine	-	?
L-Trp + O2	lipopolysaccharide and muramyl tripeptide upregulate enzyme induction through a mechanism independent of interleukin 1alpha	Homo sapiens	L-formylkynurenine	-	?

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Release 2023.1 (January 2023)