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Literature summary for 1.13.11.52 extracted from
- Purification and characterization of tryptophan dioxygenase from Streptomyces parvulus (1988), Arch. Biochem. Biophys., 261, 148-160.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-hydroxyanthranilic acid | - |
Streptomyces parvulus |  |
| actinomycin D | - |
Streptomyces parvulus | |
| Cinnabarinic acid | - |
Streptomyces parvulus | |
| CN- | 5 mM, 98% inhibition | Streptomyces parvulus | |
| D-Trp | - |
Streptomyces parvulus | |
| DL-5-fluorotryptophan | - |
Streptomyces parvulus | |
| DL-5-Methyltryptophan | - |
Streptomyces parvulus | |
| DL-alpha-methyltryptophan | - |
Streptomyces parvulus | |
| N3- | 5 mM, 5% inhibition | Streptomyces parvulus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.3 | - |
L-Trp | - |
Streptomyces parvulus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces parvulus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces parvulus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Trp + O2 | 0.7% of the activity with L-Trp | Streptomyces parvulus | N-formyl-D-kynurenine | - |
? | |
| DL-5-fluoro-methyltryptophan + O2 | 30.6% of the activity with L-Trp | Streptomyces parvulus | ? | - |
? | |
| DL-5-methyltryptophan + O2 | 15.1% of the activity with L-Trp | Streptomyces parvulus | ? | - |
? | |
| DL-alpha-methyltryptophan + O2 | 9.0% of the activity with L-Trp | Streptomyces parvulus | alpha-methyl-N-formyl-DL-kynurenine | - |
? | |
| L-Trp + O2 | - |
Streptomyces parvulus | L-formylkynurenine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Streptomyces parvulus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | pH 6.0: about 45% of maximal activity, pH 9.0: about 40% of maximal activity | Streptomyces parvulus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | the prosthetic group is tightly bound to the enzyme | Streptomyces parvulus | |
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