Any feedback?
Literature summary for 1.13.11.52 extracted from
- Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated L-tryptophan metabolism (2005), Biochem. Biophys. Res. Commun., 338, 12-19.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme plays an important physiological role in the defense mechanism against a variety of infectious pathogens, in the regulation of T-cell function by macrophages and a subset of dendritic cells, and in the synthesis of UV filters in human lenses. Serious problems arise from the unregulated over-expression of the enzyme, which often results in a deleterious systemic Trp depletion and/or the accumulation of neurotoxin, quinolinic acidn the brain. Enzyme expression in malignant tumors helps them to avoid the immune surveillance through a local Trp depletion. The kynurenilation of the lens protein with UV filters thus appears to be the major cause of age-related cataract | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Oryctolagus cuniculus | - |
| colon | - |
Oryctolagus cuniculus | - |
| intestine | - |
Homo sapiens | - |
| kidney | - |
Oryctolagus cuniculus | - |
| large intestine | - |
Oryctolagus cuniculus | - |
| lung | - |
Oryctolagus cuniculus | - |
| lung | - |
Homo sapiens | - |
| placenta | term placenta | Homo sapiens | - |
| small intestine | - |
Oryctolagus cuniculus | - |
| spleen | - |
Oryctolagus cuniculus | - |
| stomach | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Trp + O2 | - |
Oryctolagus cuniculus | D-formylkynurenine | - |
? | |
| D-Trp + O2 | - |
Homo sapiens | D-formylkynurenine | - |
? | |
| L-Trp + O2 | - |
Oryctolagus cuniculus | L-formylkynurenine | - |
? | |
| L-Trp + O2 | - |
Homo sapiens | L-formylkynurenine | - |
? | |
| additional information | the enzyme plays an important physiological role in the defense mechanism against a variety of infectious pathogens, in the regulation of T-cell function by macrophages and a subset of dendritic cells, and in the synthesis of UV filters in human lenses. Serious problems arise from the unregulated over-expression of the enzyme, which often results in a deleterious systemic Trp depletion and/or the accumulation of neurotoxin, quinolinic acidn the brain. Enzyme expression in malignant tumors helps them to avoid the immune surveillance through a local Trp depletion. The kynurenilation of the lens protein with UV filters thus appears to be the major cause of age-related cataract | Homo sapiens | ? | - |
? | |
| serotonin + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| serotonin + O2 | - |
Homo sapiens | ? | - |
? | |
| tryptamine + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| tryptamine + O2 | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IDO | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Oryctolagus cuniculus | |
| heme | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
