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Literature summary for 1.13.11.49 extracted from

  • Geeraerts, Z.; Rodgers, K.R.; DuBois, J.L.; Lukat-Rodgers, G.S.
    Active sites of O2-evolving chlorite dismutases probed by halides and hydroxides and new iron-ligand vibrational correlations (2017), Biochemistry, 56, 4509-4524 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
R183Q mutant does not bind OH- under conditions where the wild-type enzyme is completely converted to the heme hydroxide. Mutant does not bind F- Dechloromonas aromatica
W227F mutant does not bind OH- under conditions where the wild-type enzyme is completely converted to the heme hydroxide. Mutant does not bind F- Dechloromonas aromatica

Inhibitors

Inhibitors Comment Organism Structure
chloride upon cooperative binding of Cl-, Cld remains pentacoordinate and high-spin Dechloromonas aromatica
chloride cooperative binding of Cl- to Cld drives formation of a hexacoordinate, high-spin aqua heme Klebsiella pneumoniae
fluoride fluoride coordinates to the heme iron in Cld exhibiting ny(FeIII-F) band at 390 per cm. Strong H-bond donation happens to the F- ligand Dechloromonas aromatica
fluoride fluoride coordinates to the heme iron in Cld exhibiting ny(FeIII-F) band at 385 per cm. Strong H-bond donation happens to the F- ligand Klebsiella pneumoniae

Metals/Ions

Metals/Ions Comment Organism Structure
Iron vibrational frequency correlations between either ny(FeIII-F) or ny(FeIII-OH) and ny(FeII-His) orthogonalize proximal and distal effects on the bonding between iron and exogenous pi-donor ligands Klebsiella pneumoniae
Iron vibrational frequency correlations between either ny(FeIII-F) or ny(FeIII-OH) and ny(FeII-His) orthogonalize proximal and distal effects on the bonding between iron and exogenous pi-donor ligands Dechloromonas aromatica

Organism

Organism UniProt Comment Textmining
Dechloromonas aromatica Q47CX0
-
-
Dechloromonas aromatica RCB Q47CX0
-
-
Klebsiella pneumoniae
-
-
-
Klebsiella pneumoniae MGH 78578
-
-
-

Cofactor

Cofactor Comment Organism Structure
heme
-
Dechloromonas aromatica