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Literature summary for 1.13.11.49 extracted from

  • Celis, A.I.; Geeraerts, Z.; Ngmenterebo, D.; Machovina, M.M.; Kurker, R.C.; Rajakumar, K.; Ivancich, A.; Rodgers, K.R.; Lukat-Rodgers, G.S.; DuBois, J.L.
    A dimeric chlorite dismutase exhibits O2-generating activity and acts as a chlorite antioxidant in Klebsiella pneumoniae MGH 78578 (2015), Biochemistry, 54, 434-446 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.49

Activating Compound

Activating Compound Comment Organism Structure
2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) presence of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) modestly increases turnover number Klebsiella pneumoniae
2-chloro-5,5-dimethyl-1,3-cyclohexanedione presence of 2-chloro-5,5-dimethyl-1,3-cyclohexanedione modestly increases turnover number Klebsiella pneumoniae
guaiacol presence of guaicol modestly increases turnover number Klebsiella pneumoniae

Inhibitors

Inhibitors Comment Organism Structure
Chlorite chlorite acts a suicide substrate. Loss of activity is correlated with destruction of the heme and also some degree of protein damage Klebsiella pneumoniae

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae
-
-
-
Klebsiella pneumoniae MGH 78578
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chlorite
-
 Klebsiella pneumoniae chloride + O2
-
 ?
chlorite
-
 Klebsiella pneumoniae MGH 78578 chloride + O2
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1900
-
 Chlorite pH 5.0, 20°C Klebsiella pneumoniae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
 Klebsiella pneumoniae

Cofactor

Cofactor Comment Organism Structure
heme at pH 6.0, ferric Cld exhibits a Soret band maximum at 405 nm, a broad alpha/beta band envelope at 505 nm with a small shoulder at 540 nm, and a charge transfer band at 645 nm Klebsiella pneumoniae

General Information

General Information Comment Organism
physiological function wild-type strains have a significant growth advantage in the presence of chlorate relative to a Cld knockout strain, specifically under nitrate-respiring conditions Klebsiella pneumoniae

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2500
-
 Chlorite pH 5.0, 20°C Klebsiella pneumoniae